细胞泛凋亡的分子组成及作用机制
Molecular Composition and Mechanism of Action of PANoptosis
王怡茹 1王远 1曹玲霞 1杨洁 1王书敏1
作者信息
- 1. 中国农业大学动物科学技术学院畜禽生物育种全国重点实验室,北京 100193
- 折叠
摘要
细胞程序性死亡(programmed cell death,PCD)在生物体生长发育以及免疫调节中起重要作用,是先天免疫系统的一道防线.细胞泛凋亡(PANoptosis)作为新的PCD途径,由多蛋白复合物细胞泛凋亡体(PANoptosome)调控,可以同时调控凋亡、坏死性凋亡、焦亡3种细胞程序性死亡的关键模式,从而防御多种病原体的入侵.因此,研究细胞泛凋亡的作用机制,对加深细胞死亡方式的理解、提示炎症以及疾病的发生具有重要意义.本文综述了泛凋亡的概念、作用机制、泛凋亡体的分子组成及组装方式,并提出泛凋亡体的形成是细胞发生泛凋亡的标志.本文为炎症性疾病的治疗提供新思路.
Abstract
Programmed cell death(PCD)is a line of the innate immune defense system,and plays an important role in the growth development and immune regulation of the organism.As a new PCD pathway,PANoptosis is regulated by the multi-protein complex PANoptosome,which can simultaneously regulate the three key modes of programmed cell death including pyroptosis,apoptosis and necrosis,thereby defending against invasion of various pathogens.Consequently,studying the mechanism of PANoptosis is of great significance for deepening the understanding of cell death patterns,suggesting the occurrence of inflammation and diseases.In this paper,the concept,mechanism of action,molecular composition and assembly method of PANoptosis were reviewed,then a view was proposed that the formation of PANoptosome was a sign of PANoptosis in cells.This review provides new ideas for the treatment of inflammatory diseases.
关键词
细胞泛凋亡/泛凋亡体/凋亡/坏死性凋亡/焦亡Key words
PANoptosis/PANoptosome/Apoptosis/Necrosis/Pyroptosis引用本文复制引用
基金项目
国家重点研发计划(2022YFD1300303-02)
出版年
2024
国家科技期刊平台
NSTL
万方数据