IL-33/ST2信号通路影响干细胞功能的研究进展
Research Progress on the Effect of IL-33/ST2 Signaling Pathway on Stem Cell Function
徐文杰 1华进联1
作者信息
- 1. 西北农林科技大学动物医学院陕西省干细胞工程技术研究中心,杨凌 712100
- 折叠
摘要
白细胞介素-33(interleucin 33,IL-33)是一种兼有促炎与抑炎功能的细胞因子,通过其特异性受体—肿瘤抑制因子2(suppressor of tumorigenicity 2,ST2)实现信号传导.IL-33/ST2信号通路的激活根据细胞类型的差异,调控NF-κb、TNFα、Wnt等信号通路,进而引发炎症反应以及影响干细胞的干性与分化能力.本文综述了IL-33/ST2信号通路的基本结构与组成,并且概括与之相关的干细胞功能研究的最新进展.本文通过作用机理的阐明为干细胞治疗炎症性疾病与免疫性疾病提供新思路.
Abstract
Interleucin 33(IL-33)is a cytokine with both pro-inflammatory and anti-inflammatory functions,and its signaling is mediated through its specific receptor suppressor of tumorigenicity 2(ST2).Activation of the IL-33/ST2 signaling pathway regulates NF-κb,TNFα,and Wnt signaling pathways depending on the cell type,thereby triggering inflammatory response and affecting the stemness and differentiation of stem cells.In this paper,the basic structure and composition of the IL-33/ST2 signaling pathway were reviewed,and the recent progress in stem cell function research was summarized.This review provides new ideas for the treatment of inflammatory and immune diseases by elucidating the mechanism of action of stem cells.
关键词
IL-33/ST2信号通路/干细胞/癌症干细胞/细胞治疗/炎症Key words
IL-33/ST2 signaling pathway/Stem cell/Cancer stem cell/Cell therapy/Inflammation引用本文复制引用
基金项目
国家自然科学基金(32072806)
国家自然科学基金(32372970)
国家重点研发计划(2022YFD1302201)
陕西省重点研发计划(2022NY-044)
陕西省畜牧专项(20221086)
陕西省畜牧专项(20230978)
出版年
2024
国家科技期刊平台
NSTL
万方数据