内质网应激对骨骼肌细胞影响的研究进展
Research Progress on the Effect of Endoplasmic Reticulum Stress on Skeletal Muscle Cells
刘颖 1石建凯 2郭肖蓉 3林晓 4周荣3
作者信息
- 1. 内蒙古科技大学生命科学与技术学院,包头 014010;中国农业科学院北京畜牧兽医研究所,北京 100193
- 2. 内蒙古科技大学生命科学与技术学院,包头 014010
- 3. 中国农业科学院北京畜牧兽医研究所,北京 100193
- 4. 南宁壮博生物科技有限公司,南宁 530000
- 折叠
摘要
骨骼肌对人体和畜禽均有重要意义,与身体机能及畜禽的产肉性能直接相关.当细胞受到外界刺激或内环境发生改变时,内质网(endoplasmic reticulum,ER)会引发一系列保护机制—内质网应激.内质网应激反应具有双向作用,适当的内质网应激会通过自噬、未折叠蛋白反应等行为缓解细胞对生存条件的不适应性,但是不利因素引起的持续内质网应激会影响内质网的功能,进而促进细胞凋亡.本文主要针对近年来内质网应激对骨骼肌细胞脂质代谢、细胞自噬凋亡、分化等生理过程的影响及作用机制进行综述,旨在为进一步揭示内质网应激对骨骼肌细胞的作用机制提供理论依据.
Abstract
Skeletal muscle has very important roles in both human body and livestock,related to physical function and meat production of livestock.External stimulation or the internal environment changes could make the endoplasmic reticulum(ER)to start a series of protective mechanisms,that is,ER stress.ER stress response has a two-way effect.Proper ER stress can alleviate the cell's inadaptability to living conditions through autophagy,unfolded protein reaction and other behaviors,but the continuous stress of ER caused by adverse factors will affect the normal function of ER and lead to apoptosis.This paper mainly reviewed the researches about the effects of ER stress on lipid metabolism,autophagy,apoptosis,differentiation and other physiological processes and mechanisms of skeletal muscle cells,aiming to provide a theoretical basis for studying the effect of ER stress on skeletal muscle cells.
关键词
骨骼肌细胞/内质网应激/未折叠蛋白反应/自噬/凋亡/胰岛素抵抗Key words
Skeletal muscle cells/Endoplasmic reticulum stress/Unfolded protein response/Autophagy/Apoptosis/Insulin resistance引用本文复制引用
基金项目
国家自然科学基金面上项目(31972541)
国家自然科学基金面上项目(32130102)
出版年
2024
国家科技期刊平台
NSTL
万方数据