环境微生物降解氟喹诺酮类药物的研究进展
Research Progress on Degradation of Fluoroquinolones by Environmental Microorganisms
神舒晴 1梁仪 2马嘉伟 3孙永学 2王美4
作者信息
- 1. 浙江农林大学动物科技学院·动物医学院,杭州 311300;华南农业大学兽医学院,广州 510642
- 2. 华南农业大学兽医学院,广州 510642
- 3. 浙江农林大学茶学与茶文化学院,杭州 311300
- 4. 浙江农林大学动物科技学院·动物医学院,杭州 311300;浙江省畜禽绿色生态健康养殖应用技术研究重点实验室,杭州 311300
- 折叠
摘要
氟喹诺酮类(fluoroquinolones,FQs)药物是人类医药与畜禽养殖中最常用的抗生素之一,因其用量大,在环境中广泛残留,对人类和动物健康构成潜在威胁.微生物降解是现阶段消除环境中FQs的理想方式,具有高效、绿色、成本低的特点.目前,关于微生物降解FQs的研究主要集中于降解微生物的筛选和降解产物的鉴定上.本文综述了降解FQs的细菌、真菌、微藻以及微生物降解聚生体的功能特征,并总结了常见降解途径与关键酶.本文为缓解FQs的环境残留问题提供理论基础.
Abstract
Fluoroquinolones(FQs)are one of the most commonly used antibiotics for human medicine and animal breeding.Due to their large dosage,FQs are widely retained in the environment,posing potential threat to human and animal health.Microbial degradation is an ideal way to eliminate FQs in the environment at this stage,which has the characteristics of high efficiency,green and low cost.At present,the research on microbial degradation of FQs mainly focuses on the screening of degradable microorganisms and the identification of degradation products.This paper reviewed the functional characteristics of FQs degradation of bacteria,fungi,microalgae and microorganisms,and summarized the common degradation pathways and key enzymes.This review provides a theoretical basis for alleviating the environmental residue problem of FQs.
关键词
喹诺酮类药物/生物降解/环境微生物/降解规律Key words
Fluoroquinolones/Biodegradation/Environmental microorganisms/Degradation laws引用本文复制引用
基金项目
浙江农林大学人才启动项目(2023LFR014)
出版年
2024
国家科技期刊平台
NSTL
万方数据