内质网-脂滴-线粒体互作调控动物脂质代谢的研究进展
Research Progress on Regulation of Endoplasmic Reticulum-Lipid Droplet-Mitochondrial Interactions in Animal Lipid Metabolism
王明宇 1庞卫军 1蔡瑞1
作者信息
- 1. 西北农林科技大学动物科技学院动物脂肪沉积与肌肉发育实验室,杨凌 712100
- 折叠
摘要
脂滴(lipid droplet,LD)、内质网(endoplasmic reticulum,ER)和线粒体是动物细胞中关键的细胞器,三者间互作对动物脂质代谢发挥着重要作用.ER与LD互作促进LD出芽、生长和脂质转移等,使LD能够有效地储存和分配,从而维持细胞能量平衡与脂质稳态.此外,LD与线粒体相互作用可促进线粒体有效摄取游离脂肪酸(free fatty acids,FFAs),有助于维持细胞能量供应.本文以LD为中心,梳理并总结了LD与线粒体、ER、过氧化物酶体及溶酶体等细胞器的互作机制及调控动物脂质代谢的研究进展,旨在为从细胞器的角度探究动物脂质代谢提供新思路,为畜禽肉质性状形成机理解析及人类(Homo sapiens)代谢性疾病治疗提供新的方向.
Abstract
Lipid droplet(LD),endoplasmic reticulum(ER)and mitochondria are key organelles in animal cells,and their interaction plays an important role in regulating animal lipid metabolism.ER interacts with LD to promote LD outgrowth,growth,and lipid transfer,so that LD can be efficiently stored and distributed to maintain cellular energy balance and lipid homeostasis.In addition,the interaction between LD and mitochondria promotes the efficient uptake of free fatty acids(FFAs)by mitochondria,which helps to maintain cellular energy supply.This review focuses on LD,and summarize the interactions between LD and mitochondria,ER,peroxisomes,lysosomes,and other organelles,as well as the advances of the regulation of in animal lipid metabolism.This review provides a new way of investigating lipid metabolism from the perspective of organelles,as well as a new direction for the analysis of the mechanism of formation of livestock and poultry meat traits and treatment of metabolic diseases in human(Homo sapiens).
关键词
脂滴(LD)/内质网(ER)/线粒体/细胞器互作/动物脂质代谢Key words
Lipid droplet(LD)/Endoplasmic reticulum(ER)/Mitochondria/Organelle interactions/Lipid metabolism of animals引用本文复制引用
基金项目
国家自然科学基金青年项目(32202642)
陕西省科学技术协会青年人才托举计划项目(NYKJ202203)
中央高校基本科研业务费专项(2452021128)
出版年
2024
国家科技期刊平台
NSTL
万方数据