HCV genotypes and clinical features in 595 HIV/HCV co-infected patients in Yunnan
Objective To analyze the HCV genotypes and clinical characteristics of 595 cases of HIV/HCV co-infected patients in antiretroviral outpatient clinic of Yunnan Provincial Infectious Disease Hospital,and to provide reference for the prevention and treatment of HIV/HCV.Methods The HIV/AIDS patients who were treated in the antiviral clinic of Yunnan Infectious Diseases Hospital from January 2022 to July 2023 were selected for the study,and a cross-sectional survey was used to collect basic information,HCV antibodies,HCV RNA,HCV genotype and biochemistry.Results Screening 5709 patients with HIV/AIDS,HCV antibody positive rate of 10.42％(595/5709);HCV RNA detection rate of 86.72％(516/595),HCV RNA positive rate of 47.09％(243/516).95.47％of HCV RNA positive completed HCV genetic testing,of which the proportion of each type is:type 1b(14.66％),type 2a(0.86％),type 3a(27.59％),type 3b(40.95％),type 6(14.66％),and unidentified type(1.29％).The rate of FIB-4 score＞3.25 was 37.86％among HCV RNA-positive patients.There was significant difference in hepatitis C genotyping among HIV/HCV co-infected patients with different routes of infection(P＜0.05),and the FIB-4 indexes of the genotypes 3a,3b were higher than those of the other genotypes,and the FIB-4 indexes of 3a and 3b genotypes were all statistically significance(all P＜0.05).Conclusion HCV antibody and HCV RNA positivity rates are high in HIV-infected populations,and HCV genotypes 3b and 3a are the main prevalent strains,with a high percentage of progressive liver fibrosis occurring.Screening of HCV infection in patients with HIV/AIDS is of great significance for early diagnosis and early treatment of hepatitis C.
万方数据
维普
