The pathogenesis and treatment progress of pyoderma gangrenosum
Pyoderma gangrenosum(PG)is a rare neutrophilic dermatosis that can cause painful skin ulcers.The pathogenesis of PG is complex and not yet fully understood,but current research has pointed out that it is related to neutrophil dysfunction,immune dysfunction,genetic susceptibility,etc.Due to the lack of specific biomarkers,the diagnosis of PG is difficult and prone to misdiagnosis,which can be diagnosed based on the PARACELSUS score.At present,the treatment of PG mainly relies on glucocorticoids and immunosuppressants,and biological agents have broad application prospects in the treatment of PG.
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