炎性因子在HIV/AIDS患者并发心血管疾病中的研究进展
Research progress of inflammatory factors in HIV/AIDS patients with concurrent cardiovascular diseases
毛亚超 1杜映荣2
作者信息
- 1. 大理大学公共卫生学院,云南 大理 671000
- 2. 昆明市第三人民医院,云南 昆明 650200
- 折叠
摘要
随着抗逆转录病毒治疗(anti-retroviral therapy,ART)药物的有效运用,HIV/AIDS患者生存期延长,慢性心血管疾病(cardiovascular disease,CVD)风险相应增加,CVD在HIV/AIDS患者中的发病率较高.CVD发生发展过程中炎症全程参与.细胞因子是炎症细胞释放的主要信号分子,在HIV/AIDS患者中,长期HIV感染、ART药物及其引发的血脂异常和肠道微生物易位等因素引发的促炎细胞因子的释放加速了CVD的发生.本综述初步阐述长期HIV感染、ART药物及其引发的血脂异常和肠道微生物易位等因素引发炎性因子释放间接参与CVD发生的机制,为艾滋病患者的CVD治疗提供新思路.
Abstract
With the effective use of antiretroviral therapy(ART)drugs,the survival period of HIV/AIDS patients has been prolonged,leading to an increased risk of chronic cardiovascular diseases(CVD).The incidence of CVD in HIV/AIDS patients is higher..Inflammation is involved throughout the occurrence and development of CVD.Cytokines are the main signaling molecules released by inflammatory cells.In HIV/AIDS patients,the release of pro-inflammatory cytokines accelerated by long-term HIV infection,ART drugs,and their dyslipidemia and intestinal microbiota translocation factors contributes to the occurrence of CVD.This review preliminarily elucidates the indirect involvement of inflammatory factor release in the occurrence of CVD triggered by long-term HIV infection,ART drugs,dyslipidemia and intestinal microbiota translocation,providing new insights for the treatment of CVD in AIDS patients.
关键词
炎性因子/心血管疾病/艾滋病Key words
Inflammatory factor/CVD/AIDS引用本文复制引用
出版年
2024
NETL
NSTL
万方数据