宿主免疫与HIV相关隐球菌性脑膜炎预后研究进展
Advances in the host immunity and prognosis of HIV-associated cryptococcal meningitis
赵树伟 1苏瑞 1李钰春 2董天祥 1李玉叶 1李红宾1
作者信息
- 1. 昆明医科大学第一附属医院皮肤科,云南 昆明 650032
- 2. 昆明医科大学海源学院,云南 昆明 650106
- 折叠
摘要
即使在全球开展抗逆转录病毒治疗和抗真菌药物治疗背景下,HIV相关隐球菌性脑膜炎仍然是艾滋病患者死亡的重要原因.宿主免疫状态是决定HIV相关隐球菌性脑膜炎预后的关键因素,近年来宿主免疫与HIV相关隐球菌性脑膜炎预后相关性的研究取得一些进展,本文就宿主先天免疫、适应性免疫、中枢神经系统免疫及免疫重建综合征对HIV相关隐球菌性脑膜炎预后的影响进行综述.
Abstract
Even in the context of global antiretroviral and antifungal therapy,HIV-associated cryptococcal meningitis remains an main cause of death in people with AIDS.Host immunity status is a key factor in determining the prognosis of HIV-associated cryptococcal meningitis.In recent years,some progress has been made in the study of the correlation between host immunity and the prognosis of HIV-associated cryptococcal meningitis.In this review,the host innate immunity,adaptive immunity,central nervous system immunity and immune reconditioning syndrome on the prognosis of HIV-associated cryptococcal meningitis are reviewed.
关键词
HIV相关隐球菌性脑膜炎/先天免疫/适应性免疫/中枢神经系统免疫/免疫重建综合征Key words
HIV-associated cryptococcal meningitis/Innate immunity/Adaptive immunity/Central nervous system immunity/Immune reconstitution syndrome引用本文复制引用
基金项目
云南省科技厅-昆明医科大学联合基金重点项目(202101AY070001-022)
云南省高层次人才培养支持计划名医专项(YNWR-MY-2019-026)
云南省科技厅面上项目(202201AT070327)
云南省防治艾滋病局项目()
云南省皮肤与免疫性疾病临床医学中心(ZX2019-03-02)
出版年
2024
NETL
NSTL
万方数据