调节性T细胞在银屑病发病机制和治疗中的作用
Roles of regulatory T Cells in the pathogenesis and treatment of psoriasis
曹钰婷 1沈沾婷 1杨欢1
作者信息
- 1. 重庆医科大学附属儿童医院,重庆 400015
- 折叠
摘要
银屑病是一种常见的慢性、复发性的炎症性疾病,其发病机制复杂,受基因与环境因素相互作用的影响.调节性T细胞(Tregs)是由具有多种免疫表型的细胞组成的异质群体,在调节免疫应答、抑制过度免疫反应和维持免疫稳态中发挥着重要的作用.目前研究表明,Tregs的数量、功能及表型异常是银屑病发病的重要机制.本文将对Tregs的生长发育特征以及其在银屑病发病机制和治疗中的作用进行综述,为探讨以Tregs为靶点的银屑病治疗方案提供理论依据.
Abstract
Psoriasis is a common chronic and recurrent inflammatory disease with a complex pathogenesis and is affected by the interaction between genes and environmental factors.Regulatory T cells(Tregs)are heterogeneous population of cells with multiple immunophenotypes,which play an important role in regulating immune responses,inhibiting excessive immune responses,and maintaining immune homeostasis.Current studies have shown that abnormal number,function and phenotype of Tregs are important mechanisms in the pathogenesis of psoriasis.This article reviews the growth and development characteristics of Tregs and its role in the pathogenesis and treatment of psoriasis,so as to provide a theoretical basis for exploring the treatment of psoriasis targeted by Tregs.
关键词
Tregs/调节性T细胞/银屑病Key words
Tregs/Regulatory T cells/Psoriasis引用本文复制引用
基金项目
重庆市自然科学基金(CSTB2023NSCQ-MSX0168)
出版年
2024
NETL
NSTL
万方数据