Analysis of HPV,Chlamydia trachomatis and Ureaplasma urealyticum infections among women in a hospital in Shenzhen in 2021
Objective To analyze the infection of human papilloma virus(HPV),Chlamydia trachomatis(CT),and Ureaplasma urealyticum(UU)among women in a hospital in Shenzhen,and the correlation between HPV and UU and CT infection.Methods A retrospective analysis was conducted on HPV,CT,and UU infection among women who underwent physical examinationand specialist treatment at Shenzhen Hospital in Southern Medical University from January 1 to December 31,2021.HPV genotype was detected by polymerase chain reaction(PCR)-reverse dot hybridization.CT and UU DNA were detected by PCR-fluorescent probe method.The results were analyzed with chi-square(x2)test.Results The detection samples for HPV,CT,and UU were 8489,1590,and 1363 with total positive rates of 16.54％(1404/8489),11.07％(176/1590),and 52.02％(709/1363).The positive rates of HPV,CT,and UU in the physical examination population were 15.39％(1246/8095),6.25％(9/144),and 60.00％(96/160),while 40.10％(158/394),11.55％(167/1446),and 50.96％(613/1203)were for specialist treatment population.The age groups with the highest positive rate of the three pathogens were 16～30 years old.The top five genotypes for HPV positive rate were high-risk type 52,high-risk type 53,low-risk type 81,high-risk type 58,and high-risk type 51,which were 3.71％,1.96％,1.90％,1.73％,and 1.61％,respectively.Among 1404 HPV positive cases,single genotype infection accounted for 74.43％,with 25.57％for mixed genotype infection.Among different age groups,the positive rates of HPV single genotype and mixed genotype were the highest in(16-30)years old,which were 14.19％and 7.26％,respectively,followed by the age group＞50 years old,which were 13.29％and 6.01％,respectively.HPV high-risk type 16 was easily co-infected with other genotypes(13/23)..The CT infection rate in the HPV positive group was significantly higher than that in the HPV negative group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the UU infection rate between HPV-positive group and HPV-negative group(P＞0.05).Conclusion It is necessary to strengthen education and screening for＜30 years old population with the highest positive rates of HPV,UU,and CT.High-risk genotype 52 and high-risk genotype 16 are the genotypes with the highest positive rate of HPV and the most susceptible to co-infection infection,respectively.CT infection is positively correlated with HPV infection.It is recommended to screen HPV during CT testing to detect HPV as early as possible and prevent the occurrence of cervical cancer.
万方数据
维普
