Study on the Collagen Hydrogel of Fish Skin via Laccase-Proto-catechuic Aldehyde Cross-linking
Fish skin collagen has greater application potential than mammalian proteins because it is not limited by the prevalence of Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.However,it is restricted by its poor mechanical properties and poor resistance to degradation.This work investigated the cross-linking mechanism,gel microstructure,mechanical properties and degradation resistance of collagen hydrogels prepared by the cross-linking of laccase(LAC)with protocatechuic aldehyde(PAL).Results showed that LAC could cross-link collagen to form a hydrogel.Meanwhile,the introduction of PAL enhanced the role of LAC in cross-linking collagen and improved the structural stability and degradation resistance of the resulting collagen hydrogels.The collagen cross-linked via LAC-PAL is an effective strategy for constructing collagen hydrogels.
万方数据
维普
