The paper explores the impact of gut microbiota intervention combined with levetiracetam and perampanel on the clinical therapeutic efficacy in adult patients with focal epilepsy.Patients with focal epilepsy were randomly divided into an observation group(conventional therapy+gut microbiota intervention)and a control group(conventional therapy),with 78 cases in each group.Before treatment,there were no significant differences in various indicators between the two groups(P>0.05);after treatment,patients in the observation group exhibited a reduction in seizure frequency,with an increase in the rate of seizure-free patients(92.31%)and overall effective rate(80.77%)(P<0.05),as well as improvements in quality of life and sleep quality(P<0.05).It is suggested that gut microbiota intervention combined with conventional therapy enhance the therapeutic efficacy for adult patients with focal epilepsy,providing new evidence and insights for the treatment of focal epilepsy.
关键词
肠道菌群/局灶性癫痫/癫痫患者生活质量量表-89/匹兹堡睡眠质量指数/酶联免疫吸附试验/视频脑电图
Key words
gut microbiota/focal epilepsy/quality of life in epilepsy inventory-89(QOLIE-89)/Pittsburgh sleep quality index(PSQI)/enzyme-linked immunosorbent assay/video-electroencephalography
万方数据