Study on the Correlation Between the DNA Mismatch Repair System and Early-onset Colorectal Cancer
To investigate the relationship between DNA mismatch repair(MMR)system and the pathologi-cal features and prognosis of early-onset colorectal cancer(EO-CRC),189 EO-CRC tumor tissues were collected and divided into proficient group(pMMR)and defective group(dMMR)by immunohistochemis-try.The prognosis status of the two groups was analyzed by Kaplan-Meier method.The results show that 37 samples are dMMR and 152 samples are pMMR.MLH1 and PMS2 are most missing(32.43％)in the dMMR group.The tumor location in the dMMR group is mostly in the right half of the colon(48.65％),while the tumor location in the pMMR group is mostly in the rectum(58.55％).The data of tumor size and TNM stage are statistically different(P＜0.05),and the overall survival is statistically different(Log-rank x2=4.19,P＜0.05)between the two groups.This indicates that the dMMR group among EO-CRC patients has special pathological characteristics and a better prognosis,providing references for the early diagnosis and precise treatment of EO-CRC patients.
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