Preparation of Cargo Conversion Nanomaterials for Targeted Therapy of Atherosclerosis
β-cyclodextrin-rapamycin nanomaterials were designed and prepared by host-guest self-assembly to explore a therapeutic approach targeting both abnormal lipid deposition and inflammatory cell aggrega-tion in the intima of atherosclerosis.The affinity of β-cyclodextrin to rapamycin and cholesterol was tested by competitive binding assay in vitro.At the same time,RAW 264.7 cells were induced to become inflam-matory cells,and the anti-inflammatory and cholesterol scavenging effects of β-cyclodextrin-rapamycin nanomaterial on inflammatory cells were detected in vitro.Studies show that β-cyclodextrin has a higher affinity for cholesterol than rapamycin.β-cyclodextrin binds to cholesterol and simultaneously releases ra-pamycin,which can realize the combined treatment of atherosclerosis.
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