首页|Anti-inflammatory and Immunomodulatory Effects of Marine n-3 Polyunsaturated Fatty Acids on Human Health and Diseases

Anti-inflammatory and Immunomodulatory Effects of Marine n-3 Polyunsaturated Fatty Acids on Human Health and Diseases

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The pharmaceutical effects of n-3 polyunsaturated fatty acids (n-3 PUFAs) as dietary nutrients on human health and diseases have gained much attention and are investigated for decades.Docosahexaenoic acid (DHA),eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA) are the three major n-3 PUFAs enriched in marine organisms,such as fish,shrimp,algae,and so on.It has been well known that n-3 PUFAs,especially DHA and EPA,are beneficial in reducing the risk of cardiovascular and cerebrovascular diseases.Accumulating evidence suggests that n-3 PUFAs might cure inflammatory diseases through several mechanisms,such as plasma membrane remodeling of lymphocytes,down-regulating pro-inflammatory cytokines,and altemating adhesion molecule expressions.Several molecular targets of n-3 PUFAs on immune-regulation have also been identified,such as GPR120 (FFA4),protein kinase C (PKC),and PPAR-γ.However,it remains inconclusive if dietary n-3 PUFAs function the same both in vitro and in vivo based on cohort studies.This review will focus on the molecular targets and mechanisms of anti-inflammatory and immunomodulatory effects of n-3 PUFAs on human health and diseases,such as obesity,tumor,diabetes,and autoimmune diseases.

n-3 polyunsaturated fatty acidsimmune-regulationanti-inflammationmechanism

ZHANG Yiran、MIN Junxia、ZHANG Lijuan

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The First Affiliated Hospital, Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou 310000, China

Institute of Cerebrovascular Diseases, Affiliated Hospital of Qingdao University, Qingdao 266003, China

This research was supported by the Natural Science Foundation of ChinaThis research was supported by the Natural Science Foundation of ChinaKey Technology Fund of Shandong Provinceand the Taishan Scholar Fellowship of Shandong Province in China to Lijuan Zhang

91129706816725852016ZDJS07A07

2019

中国海洋大学学报(自然科学英文版)
中国海洋大学

中国海洋大学学报(自然科学英文版)

CSTPCDCSCDSCI
影响因子：0.268
ISSN：1672-5182
年,卷(期)：2019.18(2)
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