首页|A New α-Cyclopiazonic Acid Alkaloid Identified from the Weizhou Island Coral-Derived Fungus Aspergillus flavus GXIIVID 02503
A New α-Cyclopiazonic Acid Alkaloid Identified from the Weizhou Island Coral-Derived Fungus Aspergillus flavus GXIIVID 02503
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A new oxygenated tricyclic cyclopiazonic acid(CPA)alkaloid,asperorydine Q(1),along with seven known compounds,namely,asperorydines O(2)and J(3),speradine H(4),cyclopiamides A(5)and H(6),saadamysin(7),and pyrazinemethanol(8),were isolated from the coral-associated Aspergillus flavus GXIMD 02503.The structures were elucidated by physicochemical pro-perties and comprehensive spectroscopic data analysis.Compounds 1-5 and 7-8 exhibited potent inhibition of lipopolysaccharide(LPS)-induced nuclear factor-κB(NF-κB)with the IC50 values ranging from 6.5 to 21.8μmol L-1.In addition,the most potent one,pyrazinemethanol(8),dose-dependently suppressed receptor activator of NF-κB ligand(RANKL)-induced osteoclast differentiation without obvious cytotoxicity in bone marrow macrophages cells(BMMCs),suggesting it is a promising lead compound for the treat-ment of osteolytic diseases.
WANG Jiamin、LI Zhichao、ZHANG Yanting、CHEN Chunmei、CHEN Weihao、GAO Chenghai、LIU Yonghong、TAN Yanhui、LUO Xiaowei
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CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,School of Chemistry and Pharmaceutical Sciences,Guangxi Normal University,Guilin 541004,China
Institute of Marine Drugs,Guangxi University of Chinese Medicine,Nanning 530200,China
广西自然科学基金Specific Research Project of Guangxi for Research Bases and TalentsSpecial Fund for Bagui Scholars of Guangxi国家自然科学基金国家自然科学基金Key State Laboratory Talent Project of Guangxi Normal UniversityOpen Project of CAS Key Laboratory of Tropical Marine Bioresources and Ecology
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