首页|New Antibacterial Dihydropyrones Induced by Co-Culture of Penicillium crustosum PRB-2 and Penicillium citrinum HDN11-186

New Antibacterial Dihydropyrones Induced by Co-Culture of Penicillium crustosum PRB-2 and Penicillium citrinum HDN11-186

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Two new dihydropyrones,rhytismatones C(1)and D(2),and a known compound,penicillenol A1(3),were isolated from the co-culture broth of the deep-sea-derived fungus Penicillium crustosum PRB-2 and Suaeda salsa-derived endophytic fungus Peni-cillium citrinum HDN11-186.Their structures were elucidated through comprehensive analysis of nuclear magnetic resonance(NMR)spectra and mass spectra.The absolute configurations of new compounds were determined by calculating the electronic circular di-chroism(ECD)spectrum.UPLC-MS data showed that compounds 1-3 could only be detected in the media of co-culture,suggesting new biosynthetic pathways were activated in the co-cultured fungi.Compound 1 showed obvious antibacterial activities against Pro-teus sp.MMBC-1002 and Bacillus subtilis MMBC-1004 with minimum inhibitory concentration(MIC)both at 25 μmol L-1.

co-culturePenicillium crustosumPenicillium citrinumdihydropyronesantibacterial activity

YU Guihong、ZHOU Luning、WU Guangwei、LI Dehai

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Shandong Province Key Laboratory of Applied Mycology,and Qingdao International Center on Microbes Utilizing Biogas,School of Life Sciences,Qingdao Agricultural University,Qingdao 266109,China

School of Medicine and Pharmacy,and Sanya Oceanographic Institution,Ocean University of China,Qingdao 266003,China

College of Chemical Engineering,Nanjing Forestry University,Nanjing 210037,China

Laboratory for Marine Drugs and Bioproducts,Laoshan Laboratory,Qingdao 266237,China

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National Natural science Foundation of ChinaHigh-Level Talents Research Fund of Qingdao Agricultural UniversityNSFC-Shandong Joint FundMajor Project of the 14th Five-Year PlanNatural Science Foundation of Shandong ProvinceHainan Provincial Joint Project of Sanya Yazhou Bay Science and Technology CityYouth Innovation Plan of Shandong Province

41806167665/1120034U19062122022QNLM030003-1ZR2021ZD282021CXLH00122019KJM004

2024

10.1007/s11802-023-5676-4

中国海洋大学学报(自然科学英文版)
中国海洋大学

中国海洋大学学报(自然科学英文版)

CSTPCD
影响因子：0.268
ISSN：1672-5182
年,卷(期)：2024.23(1)
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