首页|Kelp Fucoidans Facilitate Vascular Recanalization via Inhibiting Excessive Activation of Platelet in Deep Venous Thrombosis Model of Mouse
Kelp Fucoidans Facilitate Vascular Recanalization via Inhibiting Excessive Activation of Platelet in Deep Venous Thrombosis Model of Mouse
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This study was carried out explore the mechanism underlying the inhibition of platelet activation by kelp fucoidans in deep venous thrombosis(DVT)mouse.In the control and sham mice,the walls of deep vein were regular and smooth with intact intima,myometrium and adventitia.The blood vessel was wrapped with the tissue and there was no thrombosis in the lumen.In the DVT model,the wall was uneven with thicken intima,myometrium and adventitia.After treated with fucoidans LF1 and LF2,the thrombus was dissolved and the blood vessel was recanalized.Compared with the control group,the ROS content,ET-1 and VWF content and the expression of PKC-β and NF-κB in the model were significantly higher(P＜0.05);these levels were significantly reduced following treatments with LF2 and LF1.Compared with H2O2 treated-HUVECs,combined LF1 and LF2 treatment resulted in significant decrease in the expression of PKC-β,NF-κB,VWF and TM protein(P＜0.05).It is clear that LF1 and LF2 reduces DVT-induced ET-1,VWF and TM expressions and production of ROS,thus inhibiting the activation of PKC-β/NF-κB signal path-way and the activation of coagulation system and ultimately reducing the formation of venous thrombus.
kelp fucoidansLF1LF2deep vein thrombosisplatelet
SUN Taohua、LIU Jie、YAN Taishan、CHEN Anjin、ZHANG Fang
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Department of Clinical Drug Trials,Qingdao Municipal Hospital,Qingdao 266100,China
Department of Pharmacy,Qingdao Municipal Hospital,Qingdao 266100,China
Special Fund for Clinical Scientific Research of Shandong Medical Association
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