首页|Tilapia Head Glycolipid Alleviates Indomethacin-Induced Gastric Ulcer via Regulating Oxidative Stress and Inflammation Through COX/PGE2 Signaling Pathway in Adult Rats
Tilapia Head Glycolipid Alleviates Indomethacin-Induced Gastric Ulcer via Regulating Oxidative Stress and Inflammation Through COX/PGE2 Signaling Pathway in Adult Rats
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The aim of this experiment was to investigate the ameliorative effect and molecular mechanism of tilapia head glycoli-pid(TH-GL)on indomcthacin(IDM)-induced gastric ulcer in male Sprague Dawley(SD)rats.The gastric ulcer model was establish-ed by oral administration of 30 mg kg-1 IDM after 7 days of TH-GL or omeprazole(OME)administration in rats.Then the macrosco-pic gastric injury symptoms,gastric mucosa protective factor cyclooxygenase 1(COX-1),cyclooxygenase 2(COX-2),prostaglandin E2(PGE2),the levels of oxidative stress,and inflammatory cytokine expression levels in the rats were analyzed.The experimental re-sults showed that multiple ulcers appeared on the gastric surface of the rats in the model group.Compared to the model group,TH-GL significantly alleviated gastric ulcers and reduced the gastric damage index in rats.In addition,TH-GL significantly promoted the ex-pression of constitutive enzyme COX-1 while inhibited the expression of inducible enzyme COX-2,and make PGE2 maintain at nor-mal levels.TH-GL also inhibited oxidative stress and inflammatory responses,increased superoxide dismutase(SOD)activity and glu-tathione(GSH)content,decreased the level of malondialdehyde(MDA)and the content of pro-inflammatory factor.In conclusion,these results suggested that TH-GL could maintain the expression levels of COX-1 and PGE2 while inhibit the expression of COX-2 in the gastric of rat and then prevent IDM-induced gastric ulcer,which may be related to the regulation of oxidative stress and inflammatory response.Therefore,TH-GL might be a new option for the prevention of gastric diseases induced by IDM.
tilapia head glycolipidindomethacingastric ulceroxidative stressinflammation
WANG Bohui、WU Haixing、SHAO Mingyang、JIANG Mengqi、SU Ruiheng、GAO Xia、XIA Guanghua、SHI Haohao、SHEN Xuanri
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Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in South China Sea,College of Food Science and Technology,Hainan University,Haikou 570228,China
Collaborative Innovation Center of Marine Food Deep Processing,Dalian Polytechnic University,Dalian 116000,China
College of Food and Engineering,Hainan Tropical Ocean University,Sanya 572022,China
National Key R&D Programs of ChinaHainan Provincial Natural Science Foundation of China
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