首页|Recent Advances of Bioactive Marine Natural Products in Drug Discovery

Recent Advances of Bioactive Marine Natural Products in Drug Discovery

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Marine natural products(MNPs)are valuable resources for drug development.To date,17 drugs from marine sources are in clinical use,and 33 pharmaceutical compounds are in clinical trials.Presently the success of drug development from the marine resources is higher than the industry average.It is a feasible strategy to conduct the discovery of drug-lead compounds based on ma-rine chemical ecology by fully exploiting the pharmacological potential of marine chemical defense matters.In the search for bioac-tive MNPs,our group has constructed a biological resources library including more than 1500 strains of fungi.Focusing on the strate-gy of Blue Drug Library,we have discovered a series of novel MNPs with abundant biological functions.Highly efficient and scal-able total synthesis of(+)-aniduquinolone A(44)and pesimquinolone I(48)have been completed,which will facilitate access to suf-ficient quantities of candidates for in vivo pharmacological and toxicological studies.As a nucleoprotein(NP)inhibitor,QLA(75)pos-sesses significant anti-influenza A virus(IAV)activities both in vitro and in vivo.CHNQD-00803(76)is a potent and selective AMP-activated kinase(AMPK)activator that can effectively inhibit metabolic disorders and metabolic dysfunction-associated steatohepa-titis(MASH)progression.Moreover,we identified two new candidate molecules with potent anti-hepatocellular carcinoma effects.Particularly,as a natural guanine-nucleotide exchange factors for ADP-ribosylation factor GTPases(Arf-GEFs)inhibitor prodrug,CHNQD-01255(78)is qualified to be developed as a targeted candidate anticancer drug,which may be promising to apply for can-cer immunotherapy.Hence,it is evident that MNPs play an important role in drug development.

marine medicinal organismsnatural productsmarine drugdiscovery and optimizationdrug development

ZHANG Qun、LV Liuxia、WANG Wenhui、WEI Meiyan、GU Yucheng、SHAO Changlun

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Key Laboratory of Marine Drugs,Ministry of Education of China,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266100,China

Laboratory for Marine Drugs and Bioproducts,Qingdao Marine Science and Technology Center,Qingdao 266237,China

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158,China

Syngenta Jealott's Hill International Research Centre,Bracknell,Berkshire RG42 6EY,UK

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Syngenta for the fellowshipShandong Province Special Fund'Frontier Technology and Free Exploration'from Laoshan LaboratoryNational Natural science Foundation of ChinaSpecial Funds of Shandong Province for Qingdao National Laboratory of Marine Science and TechnologyState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,Guangxi Normal UniversityNational Key Research and Development Program of ChinaInnovation Center for Academicians of Hainan ProvinceFundamental Research Funds for the Central Universities

8-01423761162022QN LM030003CMEMR2023-B162022YFC2601305202461059

2024

10.1007/s11802-024-5975-4

中国海洋大学学报(自然科学英文版)
中国海洋大学

中国海洋大学学报(自然科学英文版)

CSTPCD
影响因子：0.268
ISSN：1672-5182
年,卷(期)：2024.23(5)
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