Study on the Combination Rule of Cassia Seed in Tibetan Medicine and the Mechanism of the Common Drug Group"Chu Ser Man Gsum"in Treating Pruritus
Objective To investigate the combination rules of the traditional Cassia seed in Tibetan medicine and its mechanism in treating"Chu Ser."related diseases such as"Pruritus".Methods Data was gathered from the"Tibetan Medicine Formula Repository"concerning formulations that included Cassia seed.Using R language,frequency statistics,association rules,and hierarchical clustering were employed to analyze principal diseases treated,medication frequency,and common drug combinations.Network pharmacology was utilized to assess effective components,action targets,and pathways of common drug groups.Results A total of 201 Tibetan medicine formulations containing Cassia seed were collected,addressing 128 main diseases,with the highest frequency being skin diseases(66)and rheumatism(47),gout(44)among others.There were 647 types of medicinal materials involved,with 10 used at a frequency of≥40%,successively including Cassia seed,Hollyhock,Amber,Terminalia chebula,etc.Cassia seed is primarily paired with Hollyhock and Amber.Analysis of association rules and hierarchical clustering of Cassia seed formulations for skin diseases revealed that the combination of Cassia seed,Amber,and Hollyhock,termed the"Chu Ser Sman Gsum."in Tibetan medicine,has a high association with other groups like"Bzang Bo Drug"and"Vbras Bu Gsum.".Network pharmacology analysis on the common drug group"Cassia seed-Amber-Hollyhock"found that primary ingredients such as quercetin,β-sitosterol,and aloin might act on targets like EGFR,STAT3,and TP53,influencing pathways like the PI3K-Akt signaling pathway,calcium signaling pathway,and MAPK signaling pathway,thereby playing a role in the treatment of"Chu Ser."skin pruritus.Conclusion Preliminary analysis of the combination of Cassia seed in classical Tibetan medicine formulations revealed that it is often used with Amber and Hollyhock,which are known to dry Yellow Water and have anti-inflammatory and anti-itch properties,forming the common drug group"Cassia seed-Amber-Hollyhock".This combination reflects the Tibetan medical principle of using synergistic drugs to concentrate therapeutic effects while reducing adverse side effects.It also embodies the characteristics of Tibetan medicine,which focuses on multiple components,multiple targets,and multiple pathways.Such a widely used combination in Tibetan formulations,which balances standardized modularity with individualized diagnostic flexibility,holds significant developmental value.
Cassia seedCompatibility rulesCore drug groupChu ser sman gsumNetwork pharmacology
NETL
NSTL
万方数据
