Acute exposure to hypoxia at high altitude can damage the oxygen supply capacity and exercise endurance of the body,resulting in a state of fatigue.With the increasing number of people traveling and working on plateau,how to improve the motor function of plateau people and relieve fatigue has become one of the urgent problems to be solved in plateau medicine.The aim of this study is to investigate the protective effect of Cordyceps sinensis(300-900 mg/kg/d for 7 consecutive days)on exercise-induced fatigue in mice exposed to hypoxia at an altitude of 6 000 m(air oxygen content 11.35%).The results showed that compared to the model group,swimming fatigue time in the C.sinensis group was significantly increased,and levels of urea nitrogen serum(BUN),lactate dehydrogenase(LDH),creatine kinase(CK),creatinine(CRE)and malondialdehyde(MDA)were significantly decreased.The total serum antioxidant capacity(T-AOC),muscle glycogen and liver glycogen content have been significantly increased and pathological changes of liver and muscle tissue have significantly improved.In conclusion,C.sinensis has a good anti-hypoxic fatigue effect,and its activity is mainly achieved by improving muscle strength,enhancing antioxidant capacity,reducing exercise intensity,and regulating energy metabolism,especially the medium dose group(600 mg/kg/d)has the most stable effect.
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