Toxicological evaluation was conducted on the edible safety of bilberry lutein tablets.Acute toxicity test,genetic toxicity test(Ames test,bone marrow cell micronucleus test and sperm deformities test)and rat 30 d feeding test were conducted according to food safety toxicology evaluation procedure and method.The acute toxicity test in mice through the mouth maximum tolerated dose(MTD)>20.0 g/kg bw,belongs to the non-toxic level.The results of Ames test,bone marrow cell micronucleus test and sperm malformation were all negative,indicating that the subjects had no mutation effect.In rat 30 d feeding test,the animals were all well developed,and no abnormal changes were observed in the indexes of weight,food intake,hematology,blood biochemistry,organ coefficient and histopathology.Acute toxicology classification of bilberry lutein tablets was non-toxic and has no genetic toxicity,within the scope of this experimental dosage.Bilberry lutein tablets are safe health foods.
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