The Toxicological Safety Evaluation Study on Bilberry Lutein Tablets
Toxicological evaluation was conducted on the edible safety of bilberry lutein tablets.Acute toxicity test,genetic toxicity test(Ames test,bone marrow cell micronucleus test and sperm deformities test)and rat 30 d feeding test were conducted according to food safety toxicology evaluation procedure and method.The acute toxicity test in mice through the mouth maximum tolerated dose(MTD)>20.0 g/kg bw,belongs to the non-toxic level.The results of Ames test,bone marrow cell micronucleus test and sperm malformation were all negative,indicating that the subjects had no mutation effect.In rat 30 d feeding test,the animals were all well developed,and no abnormal changes were observed in the indexes of weight,food intake,hematology,blood biochemistry,organ coefficient and histopathology.Acute toxicology classification of bilberry lutein tablets was non-toxic and has no genetic toxicity,within the scope of this experimental dosage.Bilberry lutein tablets are safe health foods.
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