摘要
文章通过实验研究探讨了蝙蝠蛾拟青霉枸杞胶囊对小鼠免疫力增强的功能,按照人体推荐量的5、10、20 倍设置了低(0.225 g·kg-1·BW-1)、中(0.450g·kg-1·BW-1)、高(0.900 g·kg-1·BW-1)剂量组以及一组空白对照组.经过连续灌胃实验并对各项指标进行检测,测量小鼠的脾淋巴细胞增殖量、小鼠的单核-巨噬细胞碳廓清功能、NK细胞活性、体重、胸腺/体重比值、脾脏/体重比值、小鼠的迟发型变态反应、血清溶血素水平及腹腔巨噬细胞的吞噬能力,并与空白对照组比较.实验结果显示该受试物中剂量组能显著提高小鼠抗体生成细胞数及NK细胞活性,高剂量组的受试物能显著提高小鼠淋巴细胞增殖能力、抗体生成细胞数、碳廓清能力及NK细胞活性,且受试物不会对小鼠体重增长产生不良影响.依据《保健食品功能检验与评价方法》(2023年版)判定标准,蝙蝠蛾拟青霉枸杞胶囊具有增强免疫力的功能.
Abstract
The experimental study on the immunity-enhancing function of Paecilomyces hepiali and Lycium barbarum Capsule in mice was investigated.The study was conducted with low(0.225 g·kg-1·BW-1),medium(0.45 g·kg-1·BW-1),and high(0.90 g·kg-1·BW-1)dosage groups,as well as a blank control group,according to 5,10,and 20 times the recommended human dosage,respectively.After consecutive gastric gavage experiments and the testing of various indices,the proliferation of splenic lymphocytes,the carbon clearance function of mononuclear-macrophage cells,the activity of NK cells,body weight,the ratio of thymus weight to body weight,the ratio of spleen weight to body weight,the delayed-type hypersensitivity,serum hemolysin levels,and the phagocytic capacity of peritoneal macrophages in the mice were measured and compared with the blank control group.The experimental results showed that the medium-dose group of the test substance significantly increased the number of antibody-producing cells and NK cell activity in mice,and the high-dose group of the test substance significantly increased the proliferation capacity of lymphocytes,the number of antibody-producing cells,the ability of carbon contouring,and the activity of NK cells in mice,and the body weight growth of mice was not adversely affected by the test substance.According to the evaluation criteria of"Health Food Functional Testing and Evaluation Methods"(2023 edition),The Paecilomyces Hepiali and Lycium Barbarum Capsule has the function of enhancing immunity.
维普
万方数据