Element Analysis and Risk Assessment of Rheum tanguticum Cultivated in Qinghai Based on Inductively Coupled Plasma Mass Spectrometry
Objective:To determine the content of 25 inorganic elements in Rheum tanguticum cultivated in Qinghai and to investigate the correlation between these elements and the age and geographical origin of the plant,as well as to assess the health risks associated with 5 heavy metals and harmful elements present in R.tanguticum.Methods:The inorganic element content in 75 batches of R.tanguticum was analyzed using microwave digestion with nitric acid followed by Inductively Coupled Plasma Mass Spectrometry(ICP-MS).Cluster analysis and Partial Least Squares Discriminant Analysis(PLS-DA)were conducted to calculate the maximum tolerable daily intake(TDI)for the 5 heavy metals and harmful elements.Results:The content of inorganic elements in R.tanguticum showed a significant correlation with the place and year of cultivation,with 8 elements identified as differential elements.Based on the content of heavy metals and harmful elements and their corresponding TDI,the levels of Pb,Cd,As,Hg,and Cu in the 75 batches of samples were found to pose no significant risk.Conclusion:This study provides evidence for the correlation between inorganic element content and the geographical origin and cultivation period of medicinal plants.The risk assessment model developed can contribute to the refinement of safety and quality standards for R.tanguticum,and can be utilized for its quality control.
Rheum tanguticumInductively coupled plasma mass spectrometryElement analysisRisk assessmentQinghai Province
万方数据
维普
