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青海省杂多县鼠疫菌病原学特征及流行病学分析

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分析青海省杂多县鼠疫菌病原及流行病学特征,为该地区的鼠疫防控监测工作提供科学依据.对1964-1989年青海省杂多县不同宿主体内分离的21株鼠疫菌进行生化糖醇类试验、毒力因子(荚膜抗原(F1+)、毒力抗原因子(VW+)、色素沉着因子(Pgm+)、鼠疫杆菌素Ⅰ(Pst1+)检测、质粒及菌株差异区段(Different region,DFR)分型等研究.结果发现:21株菌株均为青藏高原型,90.48%的鼠疫菌4个毒力因子俱全;所有菌株均携带分子质量为6 × 106、45 × 106和65 × 106的质粒;DFR分型结果显示,5型占90.48%,32型占4.76%,1b型占4.76%.青海省杂多县鼠疫菌具备青藏高原鼠疫病原体特性,该地区鼠疫菌毒力强,应加强鼠疫监测和宣传力度,防止鼠疫波及影响加剧.
Pathogenic Characteristics and Epidemiological Significance of Yersinia Pestis in Zaduo County,Qinghai Province
To analyze the etiological characteristics and epidemiological significance of yersinia pestis in Zaduo County,Qinghai Province,and to provide scientific basis for plague prevention and control surveillance in this are-a.Biochemical glycoalcohol test,virulence factor(F1+),virulence factor(VW+),pigmentation factor(Pgm+),yersinia pestis 1(Pet1+),plasmid and bacterial difference region(different)were performed in 21 strains of Yersinia pestis isolated from different Jukings in Qinghai Province from 1964 to 1989 Region-dpr)classification and other re-search.Results All the 21 strains were Tibetan plateau type,90.48%of yersinia pestis had all the four virulence factors,and all the strains carried plasmid with molecular weight of 6 × 106,45 × 106.65 × 106.DFR typing results showed that type 5 accounted for 90.48%,type 32 accounted for 4.76%and type 1b accounted for 4.76%.The Yersinia pestis in Zaduo County of Qinghai Province has the characteristics of plague pathogen in Qinghai-Tibet Plateau,and the Yersinia pestis has strong virulence.The plague surveillance and publicity should be strengthened in this area to prevent the plague from spreading to human.

Yersinia pestisEtiologyEpidemiologyZaduo County

张晓璐、代瑞霞、熊浩明、辛有全、杨晓艳、李广辉、靳娟、张丽、李存香

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青海省地方病预防控制所,青海西宁 810021

鼠疫耶尔森菌 病原学 流行病学 杂多县

青海省医药卫生科技项目重点课题

2022-wjzd-06

2024

青海畜牧兽医杂志
青海省畜牧兽医学会 青海省畜牧兽医科学院

青海畜牧兽医杂志

影响因子:0.196
ISSN:1003-7950
年,卷(期):2024.54(4)