慢性阻塞性肺疾病患者血清VEGF、bFGF水平与肺动脉高压的相关性分析
Correlated Analysis of Serum Levels of VEGF and bFGF in Patients with Chronic Obstructive Pulmonary Disease and Pulmonary Arterial Hypertension
孙智娜1
作者信息
摘要
目的:探讨慢性阻塞性肺疾病(COPD)患者血清血管内皮生长因子(VEGF)与碱性成纤维细胞生长因子(bFGF)水平与肺动脉高压(PH)的相关性,为临床实践提供支持.方法:收集2021年1月—2022年12月我院收治的75例COPD患者为观察对象,根据患者是否发生PH情况,将发生PH患者分为观察组(44例),未发生PH患者分为对照组(31例),收集同期来我院进行健康体检者为健康组(46例).观察并比较三组患者的VEGF、bFGF水平及PASA,同时比较不同分期COPD患者(根据患者的严重程度分为急性期、缓解期、稳定期)、不同COPD合并PH患者(依据肺动脉收缩压升高的程度分为轻、中、重)的血清VEGF、bFGF水平,并分析COPD患者血清VEGF、bFGF水平与PH的相关性.结果:①观察组患者血清VEGF(256.35±18.25)ng/L、bFGF(136.52±12.62)ng/L,PASA(51.42±5.31)mmHg,均高于对照组和健康组(P＜0.05),对照组血清 VEGF(192.85±19.41)ng/L、bFGF(87.49±10.83)ng/L,PASA 为(25.17±2.61)mmHg,均高于健康组(P＜0.05).②COPD 患者急性期血清 VEGF、bFGF 水平分别为(273.65±30.36)ng/L、(135.96±13.62)ng/L,PASA 为(48.09±5.22)mmHg,均高于缓解期与稳定期(P＜0.05);COPD患者缓解期血清VEGF、bFGF水平及PASA均高于稳定期(P＜0.05).③轻度 PH 患者血清 VEGF、bFGF 水平分别为(254.02±25.97)ng/L、(135.61±14.53)ng/L,均高于中、重度PH患者(P＜0.05),中度PH患者血清VEGF、bFGF水平均高于重度PH患者(P＜0.05).④对照组血清VEGF、bFGF水平与PASA呈正相关,而观察组患者血清VEGF、bFGF水平与PASA呈负相关(P＜0.05).结论:COPD患者的血清VEGF、bFGF水平明显高于正常人,且血清VEGF、bFGF水平越高,则患者出现PH的概率越高,临床上可将血清VEGF、bFGF水平作为评估PH的重要指标.
Abstract
Objective:This paper aims to explore chronic obstructive pulmonary disease(COPD),and serum vascular endothelial growth factor in patients with COPD,VEGF and basic fiibroblast growth factor,BFGF levels and pulmonary hypertension,the correlation of PH provides support for clinical practice.Methods:75 COPD patients admitted to our hospital from January 2021 to December 2022 were collected as observation subjects.Based on whether the patients had PH or not,they were divided into an observation group(44 cases),a control group(31 cases),and a healthy group(46 cases)who came to our hospital for physical examination during the same period.The VEGF levels of three groups of patients BFGF levels and PASA were compared,and serum VEGF levels were measured in patients with different stages of COPD(classified as acute,remission,and stable according to the severity of the patient),as well as in patients with different COPD complicated with PH(classified as mild,moderate,and severe according to the degree of pulmonary artery systolic blood pressure elevation)BFGF level,and analyze the correlation between serum VEGF,bFGF levels and PH in COPD patients.Results:① The serum VEGF of the observation group patients was(256.35±18.25)ng/L,BFGF(136.52±12.62)ng/L,PASA(51.42±5.31)mmHg which was higher than that of the control group and healthy group(P＜0.05);while the serum VEGF in the control group was(192.85±19.41)ng/L,BFGF(87.49±10.83)ng/L,PASA(25.17±2.61)mmHg which was higher than that of the healthy group(P＜0.05).② The levels of bFGF were(273.65±30.36)ng/L and(135.96±13.62)ng/L,respectively,and PASA was(48.09±5.22)mmHg,which were higher than that in the remission and stable phases(P＜0.05).③ The levels of bFGF and PASA were higher than those in the stable period(P＜0.05).The levels of bFGF were(254.02±25.97)ng/L and(135.61±14.53)ng/L,respectively,which were higher than those in moderate(P＜0.05).④ The serum VEGF levels in moderate PH patients were significantly higher than those in severe PH patients The average level of bFGF water was higher than that of severe PH patients(P＜0.05).The level of bFGF was positively correlated with PASA,while the serum VEGF and the level of bFGF were negatively correlated with PASA(P＜0.05).Conclusion:Serum VEGF levels in COPD patients,the level of bFGF is significantly higher than that of normal individuals,and as serum VEGF,the higher the level of bFGF was,the higher the probability of patients developing PH was,and in clinical practice,serum VEGF and BFGF level are important criterion for evaluating PH.
关键词
慢性阻塞性肺疾病/血管内皮生长因子/碱性成纤维细胞生长因子/肺动脉高压/相关性Key words
Chronic obstructive pulmonary disease/Serum vascular endothelial growth factor/Basic fibroblast growth factor/Pulmonary arterial hypertension correlation/Relatiuity引用本文复制引用
出版年
2024
NETL
NSTL
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