经鼻高流量氧疗联合无创正压通气对急性加重期慢阻肺伴呼吸衰竭患者炎症指标及肺功能的影响
The Effect of Nasal High-flow Oxygen Therapy Combined with Non-invasive Positive Pressure Ventilation on Inflammatory Markers and Lung Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Respiratory Failure
徐有龙1
作者信息
摘要
目的:探讨经鼻高流量氧疗(HFNC)联合无创正压通气(NIPPV)对急性加重期慢阻肺(AECOPD)伴呼吸衰竭患者炎症指标及肺功能的影响.方法:收集2020年10月—2022年5月我院收治的82例AECOPD伴呼吸衰竭患者,采用随机数字表法将其分为对照组和研究组各41例.对照组采用NIPPV方法治疗,研究组采用HFNC联合NIPPV治疗,比较两组患者治疗前后痰液黏稠度、炎症指标[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、肺功能指标[用力肺活量(FVC)、1秒用力呼气容积(FEV1)、FEV1/FVC]及并发症发生情况.结果:治疗7d后,研究组患者痰液黏稠度改善效果较对照组好(P＜0.05);研究组患者FVC为(3.55±0.34)L、FEV1为(3.55±0.34)L、FEV1/FVC 为(80.44±8.42)％,均高于对照组(P＜0.05);研究组患者 IL-6 为(0.50±0.06)ng/L、TNF-α为(1.40±0.35)ng/mL,均低于对照组(P＜0.05);研究组并发症总发生率为2.44％,低于对照组(P＜0.05).结论:AECOPD伴呼吸衰竭患者采用HFNC联合NIPPV治疗利于改善痰液黏稠度,降低炎症指标水平,提高肺功能,减少并发症的发生.
Abstract
Objective:Exploring the effects of high-flow oxygen therapy(HFNC)combined with non-invasive positive pressure ventilation(NIPPV)on inflammatory markers and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with respiratory failure.Methods:82 AECOPD patients with respiratory failure admitted to our hospital from October 2020 to May 2022 were collected and randomly divided into a control group and an observation group,with 41 cases in each group.The control group was treated with NIPPV method,while the observation group was treated with HFNC combined with NIPPV,compare the sputum viscosity,inflammatory indicators[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],lung function indicators[forced vital capacity(FVC),forced expiratory volume at 1 second(FEV1),FEV1/FVC],and incidence of complications were compared between the two groups of patients before and after treatment.Results:After 7 days of treatment,the improvement effect of sputum viscosity in the study group was better than that in the control group(P＜0.05).The FVC of the observation group patients was(3.55±0.34)L,the FEV1 was(3.55±0.34)L,and the FEV1/FVC was(80.44±8.42)％,all of which were higher than those of the control group(P＜0.05).The IL-6 level and TNF-α in the observation group were(0.50±0.06)ng/L and(1.40±0.35)ng/mL,respectively,lower than those in the control group(P＜0.05);The total incidence of complications in the observation group(2.44％)was lower than that in the control group(P＜0.05).Conclusion:HFNC combined with NIPPV treatment is beneficial for improving sputum viscosity,reducing inflammation levels,improving lung function,and reducing complications in AECOPD patients with respiratory failure.
关键词
急性加重期慢阻肺/呼吸衰竭/经鼻高流量氧疗/无创正压通气/炎症指标/肺功能Key words
Acute exacerbation of chronic obstructive pulmonary disease/Respiratory failure/Nasal high flow oxygen therapy/Non inuasive positive pressure ventilation/Inflammatory indicators/Pulmonary function引用本文复制引用
出版年
2024
NETL
NSTL
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