This paper analyzes the causes of runaway temperature in the catalyst bed of fixed-bed reactors during the start-up course of chemical-type methyl tert-butyl ether(MTBE)units.Drawing on the design concept of"start-up oil"in pyrolysis gasoline hydro-genation units,the concept of"start-up inert C4"is introduced,and control measures for cat-alyst bed runaway temperature under different operating conditions are proposed to effectively solve the runaway temperature issue.