Study on the lipid metabolism of the water extract of Duyun Maojian black tea in hyperlipidemia mice
Objective:To observe the effect of water extract of Duyun Maojian black tea on lipid metabo-lism in hyperlipidemic mice,clarify its health effect on hyperlipidemia,and provide theoretical support for the promotion of Duyun Maojian black tea.Methods:After successfully establishing a hyperlipidemia model,the mice were divided into a model control group(MC group),a positive control group(PC group),a low-dose Duyun Maojian group(HL group),a medium dose group(HMgroup),and a high-dose group(HH group),with 10 mice in each group;Meanwhile,a blank control group(NC group)of 10 mice was set up.After group-ing,except for the model control group,other groups continued to receive a high-fat diet.The MC group did not receive any intervention,while the PC group was given a suspension of simvastatin dispersible tablets by ga-vage.The Duyun Maojian black tea group was given corresponding doses by gavage(low,medium,and high doses were 50,100,and 200 mg/kg,respectively),once a day,for 14 consecutive days of intervention.De-tect mouse organ index,serum C,TG,LDL-C,HDL-C,ALT,AST,SOD,MDA and other indicators,and observe the pathological morphology of the liver under the microscope.Results:Compared with the NC group,the liver mass and liver coefficient of mice in each modeling group were significantly increased(P＜0.05).Serum TC,TG,LDL-C,ALT,AST,and MDA were significantly increased,while serum HDL-C and SOD activities were significantly reduced.Meanwhile,the livers of mice in each modeling group showed varying de-grees of hepatic steatosis.Compared with the MC group,the PC group,HL group,HMgroup,and HH group mice showed varying degrees of body weight reduction and decreased liver coefficient(P＜0.05);The levels of serum TC,TG,LDL-C,ALT,AST,and MDA decreased to varying degrees,while the activities of HDL-C and SOD increased to varying degrees;Pathological examination of mouse liver showed varying degrees of reduc-tion in hepatic steatosis.Among them,the PC group,HM group,and HH group showed more significant effects.Conclusion:Duyun Maojian black tea can effectively regulate serum lipid metabolism,reduce lipid oxi-dation,protect liver cells,and effectively reduce the harm of hyperlipidemia to the human body.It is suitable for daily health consumption of people with hyperlipidemia.
NETL
NSTL
万方数据
维普
