Effect of Nalmefene Hydrochloride in Adjuvant Treatment of Patients withSevere Craniocerebral Injury and Its Effect on Neurological Function
Objective:To investigate the efficacy of nalmefene hydrochloride as an adjunctive treatment for patients with severe traumatic brain injury and its impact on their neurological function.Methods:A total of 96 patients with severe traumatic brain injury admitted to our hospital between June 2020 and December 2022 were randomly divided into a control group(n =48)and an observation group(n =48).The control group re-ceived naloxone hydrochloride treatment,while the observation group received nalmefene hydrochloride treat-ment.The clinical efficacy,serum levels of neurotoxic factors,neurological function,and adverse reactions were selected as the observation indicators to compare the therapeutic effects of the two groups.Results:The overall effective rate of the observation group was higher than that of the control group(P＜0.05).One week after treatment,serum levels of neuron-specific enolase(NSE),beta-endorphin,and S100B were lower in the observation group compared to the control group(P＜0.05).The bispectral index(BIS)values were higher in the observation group than in the control group at 1-and 2-week follow-up(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Nalmefene hydrochloride as an adjunctive treatment for patients with severe traumatic brain injury can improve the overall efficacy of treatment,reduce serum levels of neurotoxic factors,improve neurological function,and have no significant increase in adverse reaction rate.
NETL
NSTL
万方数据
维普
