Under physiological conditions,the chemiluminescence properties based on the structure of(adamantane)-1,2-dioxocyclobutane are greatly improved,and its chemiluminescence method for the de-tection of various small molecules and biological macromolecules has received widespread attention.The chemi-luminescence probe obtained by using this structure has the advantages of no external excitation light source,no biological background signal interference,no light damage,photobleaching and high sensitivity.In this paper,the research progress of chemiluminescence detection of biological enzymes based on the structure of(adaman-tane)-1,2-dioxetane in recent years is reviewed,and the potential challenges and prospects of the chemi-luminescence platform in biological detection are discussed.
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