Clinical Efficacy of Amlodipine Besylate plus Irbesartan Hydrochlorothiazide in the Treatment of Elderly Hypertensive Patients with Concomitant Diabetes
Objective:To analyze the clinical efficacy of amlodipine besylate combined with irbesartan hydrochlorothiazide in elderly patients with hypertension and diabetes.Methods:Ninety elderly patients with hypertension and diabetes admitted to our hospital were randomly divided into two groups,with 45 patients in each group.All patients received dietary adjustments,exercise recommendations,and routine glucose-lower-ing therapy.The control group was treated with amlodipine besylate alone,while the observation group received a combination of amlodipine besylate and irbesartan hydrochlorothiazide.After an 8-week treatment course,systolic blood pressure(SBP),diastolic blood pressure(DBP),blood glucose levels,lipid profiles,and ad-verse reactions were compared between the two groups.Results:Post-treatment,there were significant differ-ences in DBP and SBP between the two groups(P>0.05),with the observation group showing lower values.Fasting plasma glucose,2-hour postprandial blood glucose(2hPBG),and glycosylated hemoglobin(HbA1c)were also lower in the observation group compared to the control group(P<0.05).Total cholesterol,triglyc-erides,and low-density lipoprotein levels were reduced more significantly in the observation group(P<0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination therapy of amlodipine besylate and irbesartan hydrochlorothiazide in elderly pa-tients with hypertension and diabetes demonstrated significant therapeutic effects and high safety profile.
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