首页|血清肝纤维化指标、HBV-DNA病毒载量联合检验在乙型肝炎肝纤维化中的评估价值

血清肝纤维化指标、HBV-DNA病毒载量联合检验在乙型肝炎肝纤维化中的评估价值

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目的:探究血清肝纤维化指标、HBV-DNA病毒载量联合检验在乙型肝炎肝纤维化中的评估价值.方法:选取2022年1月至2023年5月本院收治的100例乙型肝炎肝纤维化患者作为观察组,并选择同期100例慢性乙型肝炎患者作为对照组.分别采用化学发光法和荧光定量PCR法检测两组患者肝纤维化指标及HBV-DNA水平,并比较分析其与乙型肝炎肝纤维化的关系.结果:观察组透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PC Ⅲ)、Ⅳ型胶原(Ⅳ-C)水平均显著高于对照组(P<0.05);HBV-DNA水平显著低于对照组(P<0.05).结论:HBV在慢性乙型肝炎患者具有高度复制性,在肝纤维化阶段复制水平下降.随着乙肝的进一步发展,肝纤维化指标水平逐渐升高.联合检测肝纤维化指标和HBV-DNA病毒载量对临床诊断乙型肝炎肝纤维化有一定的参考价值.
Evaluation of the Combined Use of Serum Liver Fibrosis Markers and HBV-DNA Viral Load in Assessing Hepatitis B-Related Liver Fibrosis
Objective:To investigate the combined evaluation value of serum liver fibrosis markers and HBV-DNA viral load in assessing hepatitis B-related liver fibrosis.Methods:From January 2022 to May 2023,100 patients with hepatitis B-related liver fibrosis admitted to our hospital were selected as the observa-tion group,and 100 patients with chronic hepatitis B during the same period were chosen as the control group.Serum levels of liver fibrosis markers(hyaluronic acid[HA],laminin[LN],type Ⅲ procollagen[PC Ⅲ],and type Ⅳ collagen[Ⅳ-C])and HBV-DNA were detected using chemiluminescence and fluorescent quan-titative PCR methods,respectively.Relationships between these markers and hepatitis B-related liver fibrosis were compared and analyzed.Results:Levels of HA,LN,PC Ⅲ,and Ⅳ-C were significantly higher in the observation group compared to the control group(P<0.05),while the HBV-DNA level was significantly lower in the observation group(P<0.05).Conclusion:HBV exhibits high replicative activity in patients with chronic hepatitis B,which decreases during the liver fibrosis stage.As hepatitis B progresses,levels of liv-er fibrosis markers gradually increase.The combined detection of liver fibrosis markers and HBV-DNA viral load provides a certain reference value for the clinical diagnosis of hepatitis B-related liver fibrosis.

Liver fibrosis markersHBV-DNACombined testingHepatitis B-related liver fibrosis

赵石磊、刘晓莉、张成伟

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郑州市第六人民医院,河南郑州 450000

肝纤维化指标 HBV-DNA 联合检验 乙型肝炎肝纤维化

2024

黔南民族医专学报
黔南民族医学高等专科学校

黔南民族医专学报

影响因子:0.235
ISSN:1008-4983
年,卷(期):2024.37(3)
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