Evaluation of the Combined Use of Serum Liver Fibrosis Markers and HBV-DNA Viral Load in Assessing Hepatitis B-Related Liver Fibrosis
Objective:To investigate the combined evaluation value of serum liver fibrosis markers and HBV-DNA viral load in assessing hepatitis B-related liver fibrosis.Methods:From January 2022 to May 2023,100 patients with hepatitis B-related liver fibrosis admitted to our hospital were selected as the observa-tion group,and 100 patients with chronic hepatitis B during the same period were chosen as the control group.Serum levels of liver fibrosis markers(hyaluronic acid[HA],laminin[LN],type Ⅲ procollagen[PC Ⅲ],and type Ⅳ collagen[Ⅳ-C])and HBV-DNA were detected using chemiluminescence and fluorescent quan-titative PCR methods,respectively.Relationships between these markers and hepatitis B-related liver fibrosis were compared and analyzed.Results:Levels of HA,LN,PC Ⅲ,and Ⅳ-C were significantly higher in the observation group compared to the control group(P<0.05),while the HBV-DNA level was significantly lower in the observation group(P<0.05).Conclusion:HBV exhibits high replicative activity in patients with chronic hepatitis B,which decreases during the liver fibrosis stage.As hepatitis B progresses,levels of liv-er fibrosis markers gradually increase.The combined detection of liver fibrosis markers and HBV-DNA viral load provides a certain reference value for the clinical diagnosis of hepatitis B-related liver fibrosis.