Effect of Insulin Aspart Combined with Glibenclamide on Blood Glucose Control and Adverse Reactions in Elderly Diabetic Patients
Objective:To investigate the impact of combined treatment with insulin aspart and glib-enclamide on glycemic indicators and adverse reactions in elderly diabetic patients.Methods:A total of 100 di-abetic patients admitted to our hospital from March 2021 to March 2023 were randomly divided into two groups,with 50 patients in each group.The control group received insulin aspart treatment,while the observation group received a combination therapy of insulin aspart and glibenclamide.The changes in glucose metabolism and isletβ-cell function were observed in both groups.The levels of homocysteine(HCY),cystatin C(CysC),galac-tosemia(GAL),and irisin were measured,and the occurrence of adverse reactions was recorded in detail.Results:Before treatment,there were no significant differences in glucose metabolism levels between the two groups(P＞0.05).After treatment,the levels of FPG,2hPG,and HbA1c in the observation group were lower than those in the control group(P＜0.05).Before treatment,there were no significant differences in islet β-cell function between the two groups(P＞0.05).After treatment,the HOMA-βI30/ΔG30 ratio in the observation group was significantly higher than that in the control group,while the levels of HOMA-IR and FINS were significantly lower(P＜0.05).Regarding HCY,CysC,GAL,and irisin levels,there were no sig-nificant differences between the two groups before intervention(P＞0.05).After intervention,the levels of HCY,CysC,and GAL in the observation group were significantly lower than those in the control group,while the irisin level was significantly higher(P＜0.05).The incidence of adverse reactions in the observation group was significantly lower than that in the control group(P＜0.05).Conclusion:The combined treatment regimen of insulin aspart and glibenclamide has a positive effect on enhancing insulin sensitivity in elderly dia-betic patients,promoting glucose metabolism,and effectively controlling blood glucose levels.
万方数据
维普
