摘要
目的:本实验通过建立高脂血症大鼠模型,研究自拟平调降脂茶对高脂血症大鼠的降脂保肝作用.方法:将60只SD大鼠,随机分成6组,每组10只,其中1组为正常饲料喂养的空白对照组,其余5组SD大鼠予高脂饲料喂养3周后随机安排为模型对照组、平调降脂茶低剂量组、平调降脂茶中剂量组、平调降脂茶高剂量组(0.625 g/kg、1.25 g/kg、2.5 g/kg灌胃给药)、阳性对照组(非诺贝特,5 mg/kg).空白对照组、模型对照组给予同等体积的蒸馏水,持续24 d.检测大鼠血清中的总胆固醇水平(Serum total cholesterol,TC)、甘油三酯水平(Triglyceride,TG)、低密度脂蛋白胆固醇水平(Low density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇水平(High density lipopro-tein cholesterol,HDL-C)、动脉粥样硬化指数(Atherosclerosis index,AI)、谷丙转氨酶水平(Glutamic-pyruvic trans-aminase,ALT)、谷草转氨酶水平(Glutamic oxalacetic transaminase,AST).结果:与空白对照组相比,模型组大鼠TC、TG、LDL-C、AI、ALT、AST含量升高,HDL-C含量降低,且具有显著性差异(P＜0.01).与模型组比,各给药组上述指标均明显改善(P＜0.05).结论:综合而言,自拟平调降脂茶对高脂血症大鼠模型血脂及肝脏有明显的调节作用,调节效果为自拟平调降脂茶高剂量组＞自拟平调降脂茶中剂量组＞自拟平调降脂茶低剂量组.
Abstract
Objective:This study aimed to investigate the lipid-lowering and hepatoprotective effects of self-formulated Pingdiao hypolipidemic tea in a hyperlipidemic rat model.Methods:Sixty Sprague-Dawley(SD)rats were randomly divided into six groups,with ten rats in each group.One group served as the blank control group and was fed a normal diet,while the remai-ning five groups were fed a high-fat diet for three weeks to induce hyperlipidemia.These five groups were then subdivided into the model control group,low-dose Pingdiao hypolipidemic tea group,medium-dose Pingdiao hypolipidemic tea group,high-dose Pingdiao hypolipidemic tea group(administered at doses of 0.625 g/kg,1.25 g/kg,and 2.5 g/kg,respectively),and a positive control group(fenofibrate,5 mg/kg).The blank control and model control groups received an equal volume of distilled water.Treatment lasted for 24 days.Serum levels of total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),atherosclerosis index(AI),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)were measured.Results:Compared with the blank control group,the model group exhibited significantly increased levels of TC,TG,LDL-C,AI,ALT,and AST,and decreased HDL-C lev-els(P＜0.01).Compared with the model group,all treatment groups showed significant improvements in these indicators(P＜0.05).Conclusion:In summary,self-formulated Pingdiao hypolipidemic tea demonstrated significant reg-ulatory effects on lipid profiles and liver function in hyperlipidemic rats,with the highest dose showing the most pronounced effect,followed by the medium dose and then the low dose.
维普
万方数据