Objective:To investigate the clinical efficacy of LPE plus hemofiltration in the treatment of severe infections u-sing repeated measures analysis of variance(ANOVA)to assess the clinical efficacy of CRP and PCT.Methods:20 patients with severe infections who did not respond to antibiotic treatment for 48-72 hours and met the criteria were collected.The observation group(n=10)underwent LPE plus semi-whole blood replacement therapy,while the control group(n=10)received conven-tional antibiotic therapy for anti-infection.The evaluation of infection in both groups before and after treatment was compared be-tween and within groups to assess the therapeutic effect.Results:The difference in the infection evaluation indicators between the observation group before and after treatment was significant(P＜0.05),while there was no signifi-cant difference in the infection evaluation indicators between the control group before and after treatment(P＞0.05).After treatment,there was a significant difference in the infection evaluation indicators between the two groups(P＜0.05);There were significant differences in the time effect,group effect,and interaction effect of CRP and PCT between the two groups(P＜0.01);The estimated marginal means of infection indicators in the two groups were compared,and the observation group showed a better reduction in infection indicators CRP and PCT after LPE plus half-blood treatment than the control group with conventional antibiotic treatment.Conclusion:The treatment regimen of LPE plus half-blood is superior to the conventional treatment regimen of antibiotic anti-infection for severe infections.
维普
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