Synthesis and characterization of chiral Boc-L-proline ether monomer
In this research,a novel chiral ether monomer was prepared via Mitsunobu reaction using 2,4,6-tribromophenol and Boc-L-prolinol as raw materials to proceeded the SN2 substitution reaction in toluene solution.Considering the reactivity,PPh3 and DIAD were selected as catalyst to promote the reaction and the target product was obtained with a yield of 53%.Afterwards,the chemical and chiral structures of the chiral monomer was further confirmed by 1H-NMR,FTIR and CD spectra.Spectra analysis indicated that the obtained ether monomer possessed optical activity and it will provide a potential possibility for further preparation of chiral separation materials.