Objective: This study on the patients with portal hypertensive gastropathy with Compound Salvia Tablet joint Omeprazole Enteric-coated Tablets related situation treatment are discussed. Methods: 100 cases of patients with portal hypertension gastropathy treated in our hospital as the research object, divided them into two groups, compared two groups of patients. Results: the treatment group two patients had obvious difference efficiency, with statistical significance, P < 0.05. Conclusion: in the treatment of portal hypertension gastropathy, Compound Salvia Tablet joint Omeprazole Enteric-coated Tablets treatment has high value in clinical application.