Determination of 2-Amino-5,6/6,7-Dichlorobenzothiazole
A method for determination the effective ingredients and impurity content of 2-Amino-5,6/6,7-dichlorobenzothiazolewas analyzed by high performance liquid chromatography.Chromatographic conditions:C18 chromatography column(150 mm × 4.6 mm,5 μm)and UV detector were used.The mobile phase was methanol-1 g/L tetramethylammonium bromide aqueous solution(60∶40,v/v),with a flow rate of 0.8 mL/min,detection wavelength of 230 nm,column temperature of 35 ℃,and injection volume of 5 μL.The results showed that the analysis took about 25 minutes,and the relative standard deviations(RSDs)of the active ingredients,3,4-dichlorophenylthiourea,and 3,4-dichloroaniline content were 0.063％,6.988％,and 5.567％,respectively.This method is easy to operate,has a short analysis time,and good precision,and can be used for product quality control.
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