Cucumis metuliferus contains vitamin C,oxidants,alkaloids,and other substances and is also a characteristic plant resource in the Cucurbitaceae family that is resistant to Meloidogyne incognita,viral disease,Fusarium wilt,and other diseases.In recent years,great achievements have been made in mining active compounds and resistance genes in Cucumis metuliferus,which has potential application value.This paper focuses on the research progress of Cucumis metuliferus from the aspects of food and drug functions,screening of resistance resources,excellent genes,and metabolism.Based on this research,the utili-zation of Cucumis metuliferus resources is prospected.