Correlation between IL-8 expression in breast cancer tissues and formation of microvasculature and lymphatic vessels in tumor and clinical significance
Objective To study the expression of interleukin-8(IL-8)in breast cancer tissues and its relationship with the formation of microvessels and lymphatic vessels in the tumor,and to explore the influence of IL-8 on the formation of microvessels and lymphatic vessels in breast cancer tissues and its clinical significance.Methods In this experiment,83 breast cancer patients who were surgically removed from the Department of Breast Surgery of the First Affiliated Hospital of Henan University of Science and Technology from January 2016 to July 2021 were selected as the research objects,all of which were invasive non-special cancers.Immunohistochemical method was used to detect the expression level of IL-8 in breast cancer tissues,and CD34 and D2-40 were used to label microvessels and lymphatic vessels in breast cancer tissues respectively.The objective is to analyze the relationship between IL-8 expression and clinicopathological features,microvessel density(MVD)and lymphatic microvessel density(MLVD)of breast cancer,and analyze the relationship between IL-8 expression and prognosis of breast cancer patients by Kaplan-Meier survival curve.Results The expression level of IL-8 in breast cancer was related to histological grade,Ki67 proliferation index and clinical stage(x2=17.308,11.389,5.768;all P＜0.05),but it was not related to age,tumor diameter,lymph node metastasis and molecular classification(all P＞0.05).The values of MVD and MLVD in the high expression group were significantly higher than those in the low expression group(t=-5.605,-4.895;all P＜0.01).Kaplan-Meier survival analysis showed that high IL-8 expression in breast cancer tissues was not associated with patient prognosis(P=0.151).Conclusion IL-8 might promote the invasion of breast cancer by promoting tumor angiogenesis and lymphatic formation.
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