The relationship between serum MIF,D-D,PCT levels and disease progression in patients with sepsis and their predictive value for prognosis
Objective To analyze the relationship between serum migration inhibitory factor(MIF),D-dimer(D-D),procalcitonin(PCT)levels and disease progression in patients with sepsis and their predictive value for prognosis.Methods The clinical data of 125 patients with sepsis admitted to the Emergency Medicine Department of the First Affiliated Hospital of Zhengzhou University from January 2020 to December 2021 were retrospectively collected as the observation group,and the physical examination data of 35 healthy subjects who underwent physical examination in the First Affiliated Hospital of Zhengzhou University during the same period were collected as the control group.The levels of serum MIF,D-D and PCT were compared between the two groups.According to different severity and treatment outcomes of sepsis patients,they were divided into sepsis group(68 cases),septic shock group(57 cases),survival group(64 cases),and death group(61 cases).The levels of serum MIF,D-D and PCT of sepsis patients with different disease severity and different treatment outcomes were compared,and the diagnostic efficacy of the above indicators alone and in combination was analyzed.Results The levels of MIF,D-D and PCT in the observation group were(53.41±3.19)ng/mL,(2.03±0.75)mg/L and(6.01±1.89)ng/mL,respectively,which were higher than those in the control group(30.27±3.02)ng/mL,(0.42± 0.02)mg/L and(1.44±0.03)ng/mL;the differences were significant(t=38.40,12.59,14.31;all P＜0.05).The serum MIF,D-D and PCT levels in the septic shock group were higher than those in the sepsis group;the differences were significant(t=5.53,3.24,3.65;all P＜0.05).Among all patients,64 cases(51.20％)survived and 61 cases(48.80％)died,and the septic shock group had a higher fatality rate(x2=4.94,P＜0.05).The serum MIF,D-D and PCT levels in the death group were higher than those in the survival group,and the differences were statistically significant(t=4.13,3.90,6.09;all P＜0.05).The results of ROC curve analysis showed that the AUC of the combined detection of serum indicators to diagnose the prognosis of sepsis patients with death was 0.903,which was higher than those of the single detection of indicators.Conclusions With the continuous progress of patients with sepsis,the levels of serum MIF,D-D and PCT gradually increased,and the changes of their levels had certain predictive value for the prognosis of patients with sepsis.Combined diagnosis was beneficial to improve the overall diagnostic efficiency.
NETL
NSTL
万方数据
