Relationship between serum Fractalkine,SDC-1,PLIN2 and pro-inflammatory/anti-inflammatory balance imbalance in patients with sepsis and its impact on prognosis
Objective To explore the relationship between serum irregular chemokine(Fractalkine),syndecan 1(SDC-1),lipid droplet coated protein 2(PLIN2)and the inflammation/anti-inflammatory imbalance of multiple organ dysfunction syndrome(MODS)secondary to sepsis,and analyze the relevant factors affecting the prognosis of patients with MODS secondary to sepsis.Methods A total of 306 patients with sepsis who were admitted to the Beijing Friendship Hospital Affiliated to Capital Medical University from May 2019 to May 2022 were selected,and divided into MODS group(75 cases)and non-MODS group(231 cases)according to whether secondary MODS occurred.The serum levels of Fractalkine,SDC-1,PLIN2,pro-inflammatory cytokines tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),IL-6 and anti-inflammatory cytokines IL-4,IL-10,IL-13 were detected in venous blood samples,and the clinical outcomes were tracked.Pearson correlation analysis was used to analyze the correlation between Fractalkine,SDC-1,PLIN2 and pro-inflammatory and anti-inflammatory cytokines.The patients with MODS were divided into death group(26 cases)and survival group(49 cases)according to whether death occurred.Multivariate logisitc regression analysis was used to analyze the prognostic factors of patients with sepsis secondary MODS.Results The levels of serum Fractalkine[(82.13±16.05)pg/mL vs.(25.43±4.37)pg/mL],SDC-1[(205.32±43.09)ng/mL vs.(69.35±12.43)ng/mL],PLIN2[(5.32±1.05)μg/dL vs.(1.89± 0.47)μg/dL],TNF-α[(40.32±9.72)ng/L vs.(18.42±3.07)ng/L],IL-1[(26.35±7.49)ng/L vs.(13.05±4.11)ng/L],IL-6[(25.31±6.37)ng/L vs.(16.35±4.19)ng/L]in the MODS group were higher than those in the non-MODS group(t=48.571,42.896,39.109,30.021,19.464,14.009;all P＜0.001),and the levels of IL-4[(26.13±5.17)ng/L vs.(35.02±6.49)ng/L],IL-10[(18.53±4.19)ng/L vs.(30.12±6.09)ng/L],IL-13[(16.35±4.27)ng/L vs.(28.16±5.49)ng/L]were lower than those in the non-MODS group(t=10.798,15.337,17.026;all P＜0.001).The levels of serum Fractalkine,SDC-1 and PLIN2 in the MODS group were positively correlated with TNF-α,IL-1 and IL-6(P＜0.05),and negatively correlated with the levels of IL-4,IL-10 and IL-13(P＜0.05).The age,shock,acute physiology and chronic health scoring system Ⅱ(APACHE Ⅱ)score,sequential organ failure assessment(SOFA)score,serum Fractalkine,SDC-1,PLIN2,TNF-α,C-reactive protein(CRP),procalcitonin(PCT),IL-1 and IL-6 levels in the death group were higher than those in the survival group.The levels of IL-4,IL-10 and IL-13 were lower than those in the survival group(P＜0.05).High SOFA score,Fractalkine,SDC-1 and PLIN2 were risk factors for poor prognosis in patients with MODS(P＜0.05).Conclusion The levels of serum Fractalkine,SDC-1 and PLIN2 were increased in patients with sepsis secondary MODS,which were related to the pro-inflammatory/anti-inflammatory imbalance and poor prognosis.
SepsisMultiple organ dysfunction syndromeFractalkineSyndecan-1Perilipin 2
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