Serum CTRP3,Ficolin-3,MIP-1α levels in T2DM patients and their correlation with concurrent DPN
Objective To investigate the levels of serum complement C1q tumor necrosis factor-associated protein 3(CTRP3),Ficolin-3,macrophage inflammatory protein-1α(MIP-1α)in patients with type 2 diabetes mellitus(T2DM)and the correlation with patients with concurrent diabetic peripheral neuropathy(DPN).Methods A total of 80 patients with T2DM treated in Beijing Nuclear Industry Hospital from January 2019 to May 2022 were selected,including 56 patients with T2DM alone and 24 patients with T2DM combined with DPN,and 50 healthy people who received physical examination in our hospital during the same period were selected as the control group.Differences in clinical indicators among the three groups of study subjects were compared,and the risk factors affecting T2DM patients with concomitant DPN were analyzed by logistic regression,and the subject's operating characteristic curve(ROC)and area under the curve(AUC)were analyzed for the diagnostic value of serum CTRP3,Ficolin-3 and MIP-1α for concomitant DPN.Results There was no statistically significant differences in clinical general information and liver and kidney function indicators among the three groups of study subjects(P＞0.05).Fasting blood glucose(FBG),glycated hemoglobin(HbA1c),insulin resistance index(HOMA-IR),total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),CTRP3,Ficolin-3,and MIP-1α were statistically significant(F=15.569,14.229,17.321,10.116,12.415,8.680,10.357,14.806,8.612,9.577;all P＜0.05).The differences in disease duration,sensory nerve conduction velocity(SNCV),and motor nerve conduction velocity(MNCV)between the T2DM alone group and the T2DM combined with DPN group patients were statistically significant(t=9.683,5.925;all P＜0.05).Correlation analysis showed that serum CTRP3,Ficolin-3,and MIP-1α levels were positively correlated with SNCV and MNCV in patients with T2DM combined with DPN(rSNCV=0.337,0.415,0.276;rMNCV=0.340,0.409,0.295;all P＜0.05).Logistic regression analysis showed that CTRP3,Ficolin-3,and MIP-1 α were all risk factors for concomitant DPN in patients with T2DM(P＜0.05).ROC curve results showed that the AUCs for MIP,Ficolin-3,MIP-1α,and the combined diagnosis of the three were 0.848(95％CI:0.786-0.910),0.856(95％CI:0.785-0.927),0.761(95％CI:0.682-0.840)and 0.916(95％CI:0.872-0.959),respectively.Conclusion The serum levels of CTRP3,Ficolin-3,and MIP-1α were significantly reduced in T2DM patients and further reduced in patients with concurrent DPN,which could be used for the clinical diagnosis of T2DM patients with concurrent DPN.
Type 2 diabetes mellitusDiabetic peripheral neuropathyComplement-C1q TNF-related protein-3Fibronectin-3Macrophage inflammatory protein-1α
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NSTL
万方数据
