Clinical significance of serum NLR,PLR and MPVLR in patients with chronic heart failure
Objective To analyze the relationship between diagnosis of chronic heart failure(CHF)and serum neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),mean platelet volume to lymphocyte ratio(MPVLR)based on propensity score matching.Methods A total of 247 patients with CHF admitted to the First Affiliated Hospital of Xinjiang Medical University from January 2021 to December 2021 were retrospectively collected as the CHF group,and 260 healthy people were selected as the control group who underwent physical examination in our hospital during the same period.Propensity score matching was used to match the two groups,and the levels of NLR,PLR and MPLR were compared between the two groups after matching.The independent risk factors of CHF were analyzed by multivariate logistic regression;the diagnostic value of NLR,PLR and MPVLR in predicting CHF were determined by constructing receiver operating characteristic curve.Results A total of 100 pairs were matched successfully.After matching,the levels of NLR(2.74±1.66),PLR(148.42±86.80)and MPVLR(6.85±3.76)in CHF group were significantly higher than those in control group(1.49±0.45),(115.73±33.05),(5.24±1.42).The differences were statistically significant(t=-7.258,-3.519,-3.998;all P＜0.01).The levels of NLR,PLR and MPVLR in CHF group were increased with the increase of New York cardiac function scale(NYHA)(t=-4.125,-3.007,-4.147;all P＜0.01).The area under the curve of NLR,PLR,MPVLR and their combination to predict CHF were 0.820(0.762-0.878),0.614(0.536-0.692),0.609(0.531-0.688)and 0.832(0.775-0.889),respectively.Multivariate logistic regression analysis showed that NLR was an independent risk factor for CHF(P＜0.01).Conclusions NLR,PLR and MPVLR were related to the diagnosis of CHF.NLR was an independent risk factor for CHF.
Heart failureNeutrophil to lymphocyte ratioPlatelet to lymphocyte ratioMean platelet volume to lymphocyte ratio
NETL
NSTL
万方数据
