Analysis of epidemiological characteristics and changes in serum factor levels of 311 cases of acute infectious diarrhea in children
Objective To explore the epidemiological characteristics and the evaluation value of serum soluble interleukin-2R(sIL-2R),serum amyloid protein(SAA)and procalcitonin(PCT)in children with infectious diarrhea.Methods A total of 11 children with acute infectious diarrhea who were treated in the Kaifeng Children's Hospital from January 2020 to January 2022 were selected.Pathogenic bacteria were examined;the clinical characteristics,serum sIL-2R,SAA and PCT levels of children with bacterial and viral infections were analyzed.Results A total of 100 cases of pathogenic bacteria were detected,including 66 cases of bacterial infection and 34 cases of viral infection.Salmonella was the main bacterial pathogen,accounting for 43.84％;rotavirus was the main virus pathogen,accounting for 52.94％.The proportions of fever,mucus,and bloody stools in children with bacterial infection were 68.18％,39.39％,and 30.30％,respectively,which were significantly higher than those in children with viral infection(32.35％,17.65％,and 5.88％),with statistical significance(x2=11.691,4.877,7.799;all P＜0.05).The serum sIL-2R,SAA and PCT in children with bacterial infection were(478.65±87.22)U/mL,(190.40±23.32)mg/L and(2.73±0.98)ng/mL,respectively,which were significantly higher than those in children with viral infection(401.12±90.41)U/mL,(126.68±20.16)mg/L,and(0.89±0.21)ng/mL,with statistical significance(t=4.159,13.532,10.796;all P＜0.05).There was no significant difference in serum levels of sIL-2R,SAA and PCT among children of different genders and ages with bacterial infection or viral infection(all P＞0.05).The areas under the receiver operating characteristic(ROC)curve of sIL-2R,SAA,PCT and combined detection to identify bacterial infection were 0.750,0.905,0.916 and 0.793,respectively(all P＜0.001).Conclusion In children with acute infectious diarrhea,Salmonella was the main bacterial pathogen and rotavirus is the main viral pathogen;the clinical symptoms of children with bacterial and viral infection were different;serum sIL-2R,SAA and PCT levels were significantly increased in children with bacterial infection,which had certain application value in diagnosing bacterial infection.
NETL
NSTL
万方数据
