HIV与COVID-19共感染患者死亡和重症风险的meta分析
The meta-analysis of risk of death and severe disease of patients with HIV and COVID-19 co-infection
莫初叶 1康旖雯 1张君涵 1袁宗祥 1王凤仪 1韦雪芹 1韦吴迪 2蒋俊俊 2梁浩 2叶力2
作者信息
- 1. 广西医科大学公共卫生学院,广西艾滋病防治研究重点实验室,广西南宁 530021
- 2. 广西医科大学公共卫生学院,广西艾滋病防治研究重点实验室,广西南宁 530021;广西医科大学再生医学与医用生物资源开发应用协同创新中心,广西南宁 530021
- 折叠
摘要
目的 评价人类免疫缺陷病毒(HIV)与新型冠状病毒肺炎(COVID-19)共感染患者的死亡和重症风险,提出基于循证的干预措施,以降低死亡和重症风险.方法 检索2020年1月 1 日-2022年3月25日PubMed、Cochrane Library、中国知网(CNKI)和中国科技期刊数据库(CSTJ)关于HIV与COVID-19共感染相关的文献.采用Newcastle-Ottawa量表评估文献质量.运用R 4.1.2软件进行meta分析.结果 本研究共纳入49篇文献,3 020 801例 COVID-19病例.HIV 与 COVID-19共感染发生率约为2.80％(95％CI:1.600～4.700).与非 HIV感染的 COVID-19患者相比,HIV与COVID-19共感染患者的重症风险更高(OR=1.341,95％CI:1.096～1.642);然而,死亡风险未增加(OR=1.093,95％CI:0.941～1.271).CD4+T细胞计数＜200/μL的 COVID-19患者比 CD4+T细胞计数≥200/μL 的患者死亡风险更高(OR=1.810,95％CI:1.573～2.081).累积meta分析显示,HIV与COVID-19共感染患者的重症累积OR值随着样本量加大逐渐增加.结论 H1V与COVID-19共感染患者发生重症的风险更高,应采取适当措施降低重症风险.HIV与COVID-19共感染患者是防疫重点人群.
Abstract
Objective Evaluated the risk of death and severity of HIV and coronavirus disease 2019(COVID-19)co-infected patients and put forward evidence-based interventions to reduce the risk of death and severity.Methods The databases of PubMed,Cochrane Library,China National Knowledge Infrastructure(CNKI),and China Science and Technology Journal(CSTJ)database were searched for studies related to HIV and COVID-19 coinfection between January 01,2020 and March 25,2022.The Newcastle-Ottawa scale(NOS)was used to assess the quality of literatures.A meta-analysis was performed with R 4.1.2 software.Results A total of 49 publications were included in the study,with 3 020 801 cases with COVID-19.The prevalence of HIV and COVID-19 co-infection was 2.80％(95％CI:1.600-4.700).Patients with HIV and COVID-19 co-infection had a higher risk of severity than COVID-19 patients with non-HIV infection(OR=1.341,95％CI:1.096-1.642);however,the risk of death had not increased(OR=1.093,95％CI:0.941-1.271).COVID-19 patients with CD4+T cell counts＜200/μL were more likely to increase the risk of death than those with CD4+T cell counts ≥200/μL(OR=1.810,95％CI:1.573-2.081).Cumulative meta-analysis showed that the cumulative OR value of severity in patients with HIV and COVID-19 co-infection gradually became larger as the sample size increased.Conclusions Patients with HIV and COVID-19 co-infection had a higher risk of severity,and should take appropriate measures to reduce the risk of severity.Patients with HIV and COVID-19 co-infection were the key population for epidemic prevention.
关键词
新型冠状病毒肺炎/人类免疫缺陷病毒/CD4+T细胞Key words
COVID-19/Human immunodeficiency virus/CD4+T cells引用本文复制引用
基金项目
国家自然科学基金(31970167)
广西自然科学基金(2021JJB140599)
出版年
2024
NETL
NSTL
万方数据