The meta-analysis of risk of death and severe disease of patients with HIV and COVID-19 co-infection
Objective Evaluated the risk of death and severity of HIV and coronavirus disease 2019(COVID-19)co-infected patients and put forward evidence-based interventions to reduce the risk of death and severity.Methods The databases of PubMed,Cochrane Library,China National Knowledge Infrastructure(CNKI),and China Science and Technology Journal(CSTJ)database were searched for studies related to HIV and COVID-19 coinfection between January 01,2020 and March 25,2022.The Newcastle-Ottawa scale(NOS)was used to assess the quality of literatures.A meta-analysis was performed with R 4.1.2 software.Results A total of 49 publications were included in the study,with 3 020 801 cases with COVID-19.The prevalence of HIV and COVID-19 co-infection was 2.80％(95％CI:1.600-4.700).Patients with HIV and COVID-19 co-infection had a higher risk of severity than COVID-19 patients with non-HIV infection(OR=1.341,95％CI:1.096-1.642);however,the risk of death had not increased(OR=1.093,95％CI:0.941-1.271).COVID-19 patients with CD4+T cell counts＜200/μL were more likely to increase the risk of death than those with CD4+T cell counts ≥200/μL(OR=1.810,95％CI:1.573-2.081).Cumulative meta-analysis showed that the cumulative OR value of severity in patients with HIV and COVID-19 co-infection gradually became larger as the sample size increased.Conclusions Patients with HIV and COVID-19 co-infection had a higher risk of severity,and should take appropriate measures to reduce the risk of severity.Patients with HIV and COVID-19 co-infection were the key population for epidemic prevention.
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