Changes and clinical significance of peripheral blood T lymphocytes in patients with different types of tuberculosis
Objective To investigate whether there was any difference in the level of peripheral blood T lymphocytes in patients with active pulmonary tuberculosis(ATB),ATB+chronic obstructive pulmonary disease(COPD),latent pulmonary tuberculosis(LTBI)and pneumonia.Methods Recruited from October 2019 to June 2020 at the Respiratory Department of Kashgar First People's Hospital patients,according to the inclusion and exclusion criteria,30 patients with ATB(ATB group),30 patients with LTBI(LTBI group),30 patients with pneumonia(pneumonia group),30 patients with ATB+COPD(ATB+COPD group)and 30 healthy physical examination subjects were selected as healthy control group.The levels of CD3+T lymphocytes,CD4+T lymphocytes,CD8+T lymphocytes and CD4+/CD8+ratio in venous blood of four groups of patients were detected by flow cytometry.Results The level of CD3+T lymphocytes,the level of CD4+T lymphocytes and the ratio of CD4+/CD8+in the ATB+COPD group were significantly lower than those in the control group,ATB group,LTBI group and pneumonia group(F=11.15,24.39,12.31;all P＜0.05).The level of CD4+T lymphocytes in ATB group was lower than that in control group and LTBI group(P＜0.05).The ratio of CD4+/CD8+in ATB group was lower than that in control group(P＜0.05).Conclusion The immune function of patients with ATB+COPD might have been damaged,and the immune damage was more serious than those patients with ATB and pneumonia.
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